Recent work suggests that DNA replication origins are regulated by the number of multiple mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the loading of MCM – the replicative helicase which initiates DNA replication and replication kinetics determined by origin's location and firing times. However, activation of MCM is heterogeneous; different origins firing at different times in different cells. Also, more MCMs are loaded in G1 than are used in S phase. These aspects of MCM biology are explained by (...) the observation that multiple MCMs are loaded at origins. Having more MCMs at early origins makes them more likely to fire, effecting differences in origin efficiency that define replication timing. Nonetheless, multiple MCM loading raises new questions, such as how they are loaded, where these MCMs reside at origins, and how their presence affects replication timing. In this review, we address these questions and discuss future avenues of research. (shrink)

Color conveys critical information about the flavor of food and drink by providing clues as to edibility, flavor identity, and flavor intensity. Despite the fact that more than 100 published papers have investigated the influence of color on flavor perception in humans, surprisingly little research has considered how cognitive and contextual constraints may mediate color–flavor interactions. In this review, we argue that the discrepancies demonstrated in previously-published color–flavor studies may, at least in part, reflect differences in the sensory expectations that (...) different people generate as a result of their prior associative experiences. We propose that color–flavor interactions in flavor perception cannot be understood solely in terms of the principles of multisensory integration but that the role of higher-level cognitive factors, such as expectations, must also be considered. (shrink)

The hidden brain has its finger on the scale when we make all of our most complex and important decisions – it decides who we fall in love with, whether we should convict someone of murder, or which way to run when someone yells “fire ...

The Objective Of This Highly Rewarding Book Indian Philosophy Of Knowledge Is To Highlight The Main Purpose Of Gaining Knowledge. The Highest Knowledge In Vedas And Upanisads Is The Knowledge Of Brahman Which Leads To Liberation. The Sankhya System Promises Complete Cessation Of All Sorrows. The Yoga Is Entirely Devoted To The Attainment Of Kaivalya. Gautama, In His Nyayasutra Asserts That Their Knowledge Would Lead To The Attainment Of The Liberation. The Vaisesika And Mimamsa Begins With The Interpretation Of Dharma (...) As The Means For Attainment Of The Worldly As Well As Transcendental Well-Being. The Buddhists Aim Of Knowledge Is To Remove Passions And To Show The Path Of Nirvana. The Removal Of Karmic Matter Is The Main Theme Of Knowledge In Jaina Philosophy. (shrink)

We are living in an algorithmic age where mathematics and computer science are coming together in powerful new ways to influence, shape and guide our behaviour and the governance of our societies. As these algorithmic governance structures proliferate, it is vital that we ensure their effectiveness and legitimacy. That is, we need to ensure that they are an effective means for achieving a legitimate policy goal that are also procedurally fair, open and unbiased. But how can we ensure that algorithmic (...) governance structures are both? This article shares the results of a collective intelligence workshop that addressed exactly this question. The workshop brought together a multidisciplinary group of scholars to consider barriers to legitimate and effective algorithmic governance and the research methods needed to address the nature and impact of specific barriers. An interactive management workshop technique was used to harness the collective intelligence of this multidisciplinary group. This method enabled participants to produce a framework and research agenda for those who are concerned about algorithmic governance. We outline this research agenda below, providing a detailed map of key research themes, questions and methods that our workshop felt ought to be pursued. This builds upon existing work on research agendas for critical algorithm studies in a unique way through the method of collective intelligence. (shrink)

Human agents draw a variety of inferences effortlessly, spontaneously, and with remarkable efficiency – as though these inferences were a reflexive response of their cognitive apparatus. Furthermore, these inferences are drawn with reference to a large body of background knowledge. This remarkable human ability seems paradoxical given the complexity of reasoning reported by researchers in artificial intelligence. It also poses a challenge for cognitive science and computational neuroscience: How can a system of simple and slow neuronlike elements represent a large (...) body of systemic knowledge and perform a range of inferences with such speed? We describe a computational model that takes a step toward addressing the cognitive science challenge and resolving the artificial intelligence paradox. We show how a connectionist network can encode millions of facts and rules involving n-ary predicates and variables and perform a class of inferences in a few hundred milliseconds. Efficient reasoning requires the rapid representation and propagation of dynamic bindings. Our model (which we refer to as SHRUTI) achieves this by representing (1) dynamic bindings as the synchronous firing of appropriate nodes, (2) rules as interconnection patterns that direct the propagation of rhythmic activity, and (3) long-term facts as temporal pattern-matching subnetworks. The model is consistent with recent neurophysiological evidence that synchronous activity occurs in the brain and may play a representational role in neural information processing. The model also makes specific psychologically significant predictions about the nature of reflexive reasoning. It identifies constraints on the form of rules that may participate in such reasoning and relates the capacity of the working memory underlying reflexive reasoning to biological parameters such as the lowest frequency at which nodes can sustain synchronous oscillations and the coarseness of synchronization. (shrink)

Providing people with information is considered an important first step in encouraging them to behave sustainably as it influences their consumption beliefs, attitudes and intentions. However, too much information can also complicate these processes and negatively affect behaviour. This is exacerbated when people have accepted the need to live a more sustainable lifestyle and attempt to enact its principles. Drawing on interview data with people committed to sustainability, we identify the contentious role of knowledge in further disrupting sustainable consumption ideals. (...) Here, knowledge is more than just information; it is familiarity and expertise or how information is acted upon. We find that more knowledge represents a source of dilemma, tension and paralysis. Our data reveal a dark side to people’s knowledge, leading to a ‘self-inflicted sustainable consumption paradox’ in their attempts to lead a sustainable consumption lifestyle. Implications for policy interventions are discussed. (shrink)

Study of Tattvacintāmaṇididhiti of Raghunātha Śiromaṇi, commentary on Pakṣatā, portion of Tattvacintāmaṇi of Gaṅgeśa, dealing with the essential nature of proposition (pakṣatā), of Navya Nyāya school in Hindu philosophy.

Although the connectionist approach has lead to elegant solutions to a number of problems in cognitive science and artificial intelligence, its suitability for dealing with problems in knowledge representation and inference has often been questioned. This paper partly answers this criticism by demonstrating that effective solutions to certain problems in knowledge representation and limited inference can be found by adopting a connectionist approach. The paper presents a connectionist realization of semantic networks, that is, it describes how knowledge about concepts, their (...) properties, and the hierarchical relationship between them may be encoded as an interpreter‐free massively parallel network of simple processing elements that can solve an interesting class of inheritance and recognition problems extremely fast—in time proportional to the depth of the conceptual hierarchy. The connectionist realization is based on an evidential formulation that leads to principled solutions to the problems of exceptions and conflicting multiple inheritance situations during inheritance, and the best‐match or partial‐match computation during recognition. The paper also identifies constraints that must be satisfied by the conceptual structure in order to arrive at an efficient parallel realization. (shrink)

This study notes three research requirements in workplace spirituality namely; need for conducting empirical studies, building on the existing research, and linking spirituality to organizational topics in general and leadership in particular. It also notes that the existing literature indicates a requirement for examining the spiritual sources of a leader’s spiritual behaviors toward subordinates. To address these research requirements in workplace spirituality, this study conducts an empirical examination of the effect of two spiritual factors—leader’s individual spirituality and organizational spirituality—on leadership (...) spiritual behaviors toward subordinates. It specifies and empirically examines a direct effects model hypothesizing direct effects of these two variables on a leader’s spiritual behaviors toward subordinates. It also specifies and empirically examines a moderating effect model hypothesizing that organizational spirituality will moderate the relationship between a leader’s individual spirituality and the leader’s spiritual behaviors toward subordinates. The results of this study provided support for the direct effects model but not for the moderating effect model. Specifically, in the direct effects model, a leader’s individual spirituality accounted for statistically significant variance in leadership spiritual behaviors toward subordinates but organizational spirituality did not. (shrink)

This article specifies a comprehensive model for workplace spirituality facilitation that integrates various views from the existing research on workplace spirituality facilitation. It outlines the significance of workplace spirituality topic and highlights its relevance to the area of ethics. It then briefly outlines the various directions the existing workplace spirituality research has taken. Based on this, it indicates that an integration of the elements from various existing research works on workplace spirituality facilitation into a comprehensive workplace spirituality facilitation model could (...) make relevant contributions to the existing workplace spirituality research. It then indicates that there are various points of focus in workplace spirituality conceptualization and facilitation views. It outlines various views from the existing research on workplace spirituality facilitation. Drawing on the elements of these various workplace spirituality facilitation views, it specifies a comprehensive model of workplace spirituality facilitation. It outlines how the various parts and linkages depicted in the comprehensive model of workplace spirituality facilitation are consistent with and are supported by the various views of workplace spirituality facilitation that it seeks to integrate. It then outlines how the comprehensive model specified can guide the future research in the area of workplace spirituality and how it can provide inputs to leadership and organization development (OD) efforts for workplace spirituality facilitation. (shrink)

This article argues why and how a participatory approach to implement corporate social responsibility (CSR) in a cluster would be beneficial for small- and medium-sized enterprises (SMEs) who are members of the NCE – Subsea cluster in Bergen, Norway. The political and strategic reasons as well as internal motivation for SMEs to incorporate CSR into their business strategies are discussed with support from relevant literature. Furthermore, we offer a discussion on the characteristics of different approaches to incorporating CSR as part (...) of business strategy and provide examples from the Norwegian context. As part of this discussion, we look into some of the clusters in Europe which have adopted a systematic approach to implement CSR as part of their agenda. We propose a means to undertake CSR as part of the cluster through a network model to address the limitations faced by the SMEs when they try to implement CSR individually. A network model (cluster approach) to CSR will motivate the uptake of CSR among SMEs when the network (cluster) is characterized by close geographical proximity and operates in the same sector. The uptake of CSR as part of the network (cluster) agenda can also lead to innovation through cooperation and competition. The particular challenges faced by the SMEs in implementing and sustaining CSR can be also minimized by being part of a network (cluster). (shrink)

An embedding of the implicational propositional intuitionistic logic into the nonmodal fragment of intuitionistic linear logic is given. The embedding preserves cut-free proofs in a proof system that is a variant of IIL. The embedding is efficient and provides an alternative proof of the PSPACE-hardness of IMALL. It exploits several proof-theoretic properties of intuitionistic implication that analyze the use of resources in IIL proofs.

Language and Materiality integrates linguistic anthropological and sociolinguistic scholarship on a range of topics: semiotic approaches to language, language commodification, sound, embodiment, mediatization, and aesthetics. Empirically rigorous, the volume engages scholars and students interested in language, its use, and meanings. It consists of three sections - 'Texts, Objects, Mediality', 'Sound, Aesthetics, Embodiment', and 'Time, Place, Circulation' - containing chapters and short commentaries, framed by a curated conversation about semiotics and materiality in anthropology. Each section theorizes intersections, connections, and relationships between (...) language and materiality across diverse topics and ethnographic contexts. The volume shows that materiality may be approached as a feature of political economy, sensual experience, aesthetics, and affective relationships in its relation to language as talk, register, genre, ideology, and acoustic object. It consists of new perspectives on materiality as a vital dimension of social life and signification in global capitalism, connecting inquiries on subjects as diverse as food, media, fonts, and music. (shrink)

Corporate Governance (CG) issues have driven organisations to set their house right. There is a continual effort by organisations to build on a good framework of policies, not only as an undertaking enforced by a regulatory body, but also to sustain and win. However, these organisations are facing a dilemma in terms of their focus priority. Is it the composition of the board or is it the employee as the stakeholder that has high determining power to reach their goals. The (...) aim of this article is to build upon a structure of enablers of good governance. The paper utilises the Interpretive Structural Modelling (ISM) methodology to understand the mutual influence among the various enablers in such a fashion that the enablers having high driving power and dependency power can be identified. (shrink)

This book, through extensive textual study, explores the Buddha's and Buddhism's uncompromising and unflinching emphasis on the centrality of ethics as against any pernicious dogmas and metaphysical beliefs, and their attempts to causally relate moral perfection to soteriological or eschatological goal. What is most admirable about Buddhism is that it integrates the vertical development of human consciousness, for which the other is the necessary condition, with the gradual development of morality. It was this emphasis which separated Siddhartha, before he attained (...) the Awakened Wisdom (bodhi), from his teachers - Alara Kalama and Uddaka Ramaputta - and it is for this reason that the Buddha calls himself and his Dhamma Patisotagami, i.e. going against the currents of the prevailing dogmas and pernicious beliefs. In brief, Buddhism is about overcoming of suffering, the greatest evil, through ethicization of human consciousness and conduct, which also takes care of the ethicization of the society and the universe. Besides, some of the essays of this book explore many other themes like Buddhist epistemology, nature of self, time, and intercultural. (shrink)

This paper addresses researchers’ call for integrating workplace spirituality with organizational literature. This paper points out that self-interest transcendence is a common aspect in the workplace spirituality concept that emerged in the last decade and also in four OB concepts – transformational leadership, organizational citizenship behavior, organizational support, and procedural justice – that emerged in OB about two decades ago. Based on this common aspect of self-interest transcendence and the temporal precedence of these four OB concepts’ emergence, it indicates that (...) these four OB concepts constitute a precursor of workplace spirituality. It places workplace spirituality in the larger context of OB␣and outlines the associated research and practice implications. (shrink)

Computational models of semantic memory exploit information about co-occurrences of words in naturally occurring text to extract information about the meaning of the words that are present in the language. Such models implicitly specify a representation of temporal context. Depending on the model, words are said to have occurred in the same context if they are presented within a moving window, within the same sentence, or within the same document. The temporal context model (TCM), which specifies a particular definition of (...) temporal context, has proved useful in the study of episodic memory. The predictive temporal context model (pTCM) uses the same definition of temporal context to generate semantic memory representations. Taken together pTCM and TCM may prove to be part of a general model of declarative memory. (shrink)

Description: 'Religion is a doing and doing what is moral'. In Buddhism, particularly, there is such a great emphasis on moral doing that is very often designated as an 'ethical religion' (silaparaka dharma). The present work seeks to study Buddhist ethics as a development process not only in terms of inner dynamics of Buddhism inherent in its doctrinal and ethical formulations but also in terms of its response to various historical compulsions which motivated its followers to introduce in its general (...) framework novelties of forms and expressions. It is hoped that such an approach would lead to a greater appreciation of Buddhist ethics both as an emergent of a unique spiritual vision and a social force. The book which is divided in six chapters cover the entire range of Buddhist development in India. The work is novel both in its approach and treatment of the subject. It studies conceptual formulations in their proper historical contexts. Modern debates on various ethical problems have been taken into account to bring about greater clarity in discussions. (shrink)

Sri Aurobindo is one of the most prominent figures in the Indian Philosophy of twentieth century and yet we barely find any mention of his work in the philosophy circles. He has written extensively on metaphysics, aesthetics, and ethics. Sri Aurobindo’s work is all-encompassing and carries marks of a deep yogic insight into both the individual self (with all its parts and their integrated working) and the universe that ultimately shares a relation of identity with the individual in secret. He (...) talks about a world-process that contains evolution qualified with involution. It is one of the most unique features of Sri Aurobindo’s philosophy. He deals with the questions of ignorance also in the most satisfying way. Sri Aurobindo has an integral vision that sees everything in the movement of one and develops the methods and practices of Integral Yoga. In his yogic vision, he not only tries to solve the problems of humanity but also attempts to make a very bold move of transforming the whole earthly existence into a divine existence through one large stride. The epistemological discussion we find in his work is deeply connected with his metaphysics. He articulates the limits and extents of reason and senses and attempts to surpass them. Sri Aurobindo is not an armchair philosopher; he attempts to salvage the human condition by empowering humanity to consciously guide the march of human evolution towards a divine future. The boldness of his vision, the originality of his philosophical work is spectacular. In this paper, I will discuss his World-process, i.e. the evolution qualified with involution. I will also discuss the epistemological foundation of his philosophy, cosmology and integral yoga psychology. For the sake of clarity in understanding, the paper is divided into five major sections starting with an introduction. Integralism is a central idea in Sri Aurobindo’s philosophy and I have tried to do justice with it throughout this paper. In the end, the paper attempts to deals with three main themes—cosmology, integral yoga psychology and integral experience. All these three themes shall bring out—The integral experience of Sri Aurobindo is deeply intertwined with his cosmology and yogic psychology and shall not be seen in isolation. Integral experience of reality is also intertwined and works in tandem with his Integral Yoga. There is a yogic exploration of oneness between the self and world that informs and shapes both his philosophical and yogic endeavors. The rationale behind undertaking this study is to question whether the observations of the physical world from the standpoint of yogic experience could suggest some new theoretical framework for the metaphysical ontology of the world. Taking perspectives from the states of consciousness described by Sri Aurobindo may furnish us with a deeper understanding of the material and metaphysical character of physical categories, such as matter, energy, force, space, and time. This paper however is an introductory overview of Aurobindo’s relevance for cosmology, psychology and integral experience which provides a philosophical framework to reinterpret and arrive at a synthetic metaphysics. (shrink)

This study aims to examine the role of hostile climate in initiating abusive supervision and the mediating role of abusive supervision between the relationship of perceived hostile climate and workplace deviance. A cross-sectional study design was employed to collect the data from the 358 respondents in manufacturing SMEs in Pakistan. Results of the study revealed that perceived hostile climate is significantly related to abusive supervision and workplace deviance. Abusive supervision is significantly related to workplace deviance and it mediates the relationship (...) between perceived hostile climate and workplace deviance. The findings of the current study give insight to the academicians and managers on the prevalence of abuse in the workplace. Further, limitations and future recommendations are given in this study. To the best of our knowledge, this study is one of its own kinds no such study has been conducted before. (shrink)

The automatic verification of large parts of mathematics has been an aim of many mathematicians from Leibniz to Hilbert. While Gödel's first incompleteness theorem showed that no computer program could automatically prove certain true theorems in mathematics, the advent of electronic computers and sophisticated software means in practice there are many quite effective systems for automated reasoning that can be used for checking mathematical proofs. This book describes the use of a computer program to check the proofs of several celebrated (...) theorems in metamathematics including those of Gödel and Church-Rosser. The computer verification using the Boyer-Moore theorem prover yields precise and rigorous proofs of these difficult theorems. It also demonstrates the range and power of automated proof checking technology. The mechanization of metamathematics itself has important implications for automated reasoning, because metatheorems can be applied as labor-saving devices to simplify proof construction. (shrink)

In what follows, we intervene in the long history of the study of curiosity to propose curiosity studies proper. Such a field, we argue, traverses the many disciplinary and experiential contexts in which curiosity appears, in order to generate theories, analytics, and practices of curiosity that are as complex and ubiquitous as the phenomenon of curiosity itself. Assuming an ecology of knowledge framework, which expressly resists academic silos and intellectual monocultures, we envision curiosity studies as an unbounded inquiry built on (...) three simple principles: (1) Curiosity is multiple; its markers shift across history, geography, species, social identities, institutions, contexts, and circumstances; therefore it requires immensely flexible analytic attention; (2) Curiosity is praxiological; far from something that is simply felt, curiosity is something that is done, expressed in behaviors, habits, architectures, and movements across physical, conceptual, and social space; and (3) Curiosity is political; its manifestations within sociocultural worlds are marked by inherited hierarchies of value among scientific methodologies, people groups, and ideologies. And yet, precisely because it is multiple, praxiological, and political, curiosity bears a keen subversive potential. It has the capacity to upend what we know, how we learn, how we relate, and what we can change. Curiosity has the capacity to become radical, to get at the root of things. We therefore propose curiosity studies not only as a field of scholarship but as a way of reimagining the world, both within the classroom and far beyond it. (shrink)

The study aims to address the existing research gap through a thematic comparison between the aesthetics of Kant and Abhinavagupta. This paper explores Kant’s notion of aesthetic judgment based on disinterestedness with Abhinavagupta’s analysis of sādhāraṇīkaraṇa. We argue that the notions of “disinterested judgment” in Kant and sādhāraṇīkaraṇa in Abhinavagupta points towards the impersonal nature of aesthetic delight which makes the universality of aesthetic experience possible. Hence, aesthetics in both Kant and Abhinavgupta are not the personal and subjective experience but (...) a kind of universality based on the ability to experience the impersonal joy. However, the notion of aesthetic delight in Kant is confined to the agreeable mental states only while in Abhinavgupta the notion of rasa includes both positive as well as the negative mental states like fear, disgust, etc. In this regard, the paper will also analyze the affinity between notion of sensus communius in Kant and sahṛdaya in Abhinavagupta which highlights the importance of aesthetic community and the impersonal nature of aesthetic delight. (shrink)